Francis Slaughter was born about 1653 in St. Mary's parish, Essex County, Virginia. He was the only child of Francis Slaughter and Elizabeth Underwood. He married Margaret Hudson about 1675. Her parents are not known. By 1685, he was Sheriff of Rappahannock County, Virginia. Francis and Margaret had five children. The will of Francis Slaughter, dated November 6, 1718, Essex County, Virginia, probated March 4 1718/9, mentioned wife Margaret, but did not mention son Robert.