Son of John Nisbet II and Mary Osborne of NC.Education: Early education at Clio School in Statesville, NC; M.D., Jefferson Medical College, Philadelphia.
In 1791, James Nisbet, M.D. moved from NC to Camden County, SC, then to Greene County, GA. In 1794, He married Penelope Cooper, native of VA., who had been brought to Green County several years earlier by her parents.
He was Justice of the Inferior Court, Greene County: December 13, 1792 - June 11, 1796. Judge Dictrict Court, Greene County: June 11, 1796 - February 14, 1799. He was the largest taxpayer in Greene County in 1801.He was the first educated physician to settle west of Augusta, GA. He was a member of the convention that framed the GA Constitution of 1798.
He moved to Athens, GA about 1819 to educate his sons at Franklin College. He practiced medicine and farmed in the Cobb-ham area of Athens and was an Elder of the Presbyterian Church for 25 years. Besides practicing medicine, he was active in the 1811 Legislature and was a charter Trustee of Franklin College, now University of Georgia, for twelve years. Born at two year intervals were children Milus, John (died young), Eugenius, Emily, Mary, Sarah, James, Franklin, Ophelia and a 2nd son named John.