1840 Census: RESIDENCE: X Creek Tp, Washington Co, Pennsylvania; Head of Family: Peter Perrine; Free White Persons, incl. Head: Males: one age 5-10 (grdchld: Peter, John or Robert?), one age 70-80 (Peter, the Head?); Females: one age 30-40 (Margaret, dghtr-in-law?), one age 70-80 (Sarah, spouse?); Free Colored Persons: 0.{ancestry.com}

1850 US Census (Aug 21?): RESIDENCE/OCCUPATION: Dwelling #180, Cross Creek Township, Washington Co., Pennsylvania; Head: Isaac Perrine, age 47, FARMER, Value of Real Estate Owned: 10,000, b. Pennsylvania; Margaret Perrine, age 44, b. Pennsylvania; Peter Perrine, age 19, est. b. abt 1831; John, age 19; Robert, age 17; Margaret, age 15; Isaac H. age 13; Rebecca ?, age 11; Samuel S?, age 8; Mary, age 6; James, age 4. {ancestry.com}

MOTHER'S RESIDENCE?: 1850 Census (Aug 21?): (Previous census entry:) Dwelling #179, Cross Creek Township, Washington County, Pennsylvania; Head: SARAH PERRINE, age 88, est. b. 1762, b. N. J.{ancestry.com}

1860, Feb. 18 --- DEATH OF SPOUSE: Margaret died at age 53. MARY Irwin, spouse of Isaac Harris Perrine; Another record from same source lists;Margaret Irwin; spouse of Isaac Perrine, matching children.[Pennsylvania, Death Certs]{ancestry.com}

1860 US Census (7 Sept.): RESIDENCE/OCCUPATION: Post Office: Cross Creek Village. Dwelling #1393, Cross Creek Township, Washington Co., Pennsylvania; Head: Isaac Perrine, age 57, FARMER, value of real estate: 8400, value of personal estate: 54620, b. Pennsylvania; Peter, age 29, Professor, value of personal estate: 1820; Robert, age 27, Speculater?, real estate: 10500, personal estate: 8895; Margaret, age 24; I. Harris, age 22, Farmer, personal estate: 1000; Rebecca, age 20; Samuel S. age 16; Mary, age 14.(See image){ancestry.com}

History written in 1882: Benjamin removed to Harmon's Creek, where he lived and died, and ISAAC remained upon the old homestead. ISAAC PERRINE'S sons were Peter, John, Robert, Isaac H., Samuel, and James. Peter is in Steubenville, Ohio, John and Samuel live in Burgettstown, Isaac H. went to the West, and Robert occupies the old Perrine farm, as did his father before him.{Crumrine,Hstry,WshCo,Penn,188

1869, Feb. 11 --- WILL SIGNED: I, Isaac Perrine of Cross Creek Township Washington County Pennsylvania being of sound mind and memory (though weak in body)---;son John Perrine;;son Robert Perrine;son Isaac Harris Perrine;, ;son S S Perrine;,;daughter Mary Perrine;,;daughter Eliza that is married to Joseph Ralston;, ;my daughter who is married to Arnold Lee;,;daughter Margaret that is married to A Metcalf;,;daughter Rebecca Jane that is married to Dr Hartman;I appoint Francis Cunningham and S S Perrine my Executor---;In witness whereoff I have herunto set my hand and affixed my seal this Eleventh day of Feb Eighteen hundred & Sixty nine. Isaac Perrine&;[Pennsylvania, Wills and Probate Records] {ancestry.com}