Born on his parents farm, near Millville, Lincoln Co., TN.

All 7 sons of CW McGuire and Sarah Meloney served the Confederacy. Calvin, along with his brother Cornelius N. (killed at Fredericksburg) enlisted April 29, 1861, at Boons Hill, as privates, Co., K, 1st TN Infantry, under Col. Peter Turney. The regiment took part in the battles of Winchester and 1st Manassas. June 1861, Calvin was elected 2nd Lt. and sent to the Peninsula. April 1862 he was promoted to 1st Lt. He was acting assistant surgeon on the field during the battle of Seven Pines/Fair Oaks and the 7 Days battles around Richmond. June 1862 he was promoted to Surgeon (Major), after which he served in engagements at Harper's Ferry, Sharpsburg, Fredericksburg, Chancellorsville, Gettysburg, The Wilderness, Spottsylvania Court House, all operations around Richmond and Petersburg, and the Appomattox campaign. After Chancellorsville, he was promoted to Senior Surgeon, Archer's TN brigade, Army of Northern VA. He surrendered at Appomatox Court House April 9, 1865 (paroled April 10). Parole records show; C.B. McGuire, Surgeon, 1st TN, 5'11", blue eyes, dark hair, fair complexion. One site states Calvin was General Robert E. Lee's personal physician (though they did not provide the source of the info and I have not yet found confirmation).

In 1860, Lizzie Green's family lived 1 house from Calvin's older brother, Wm "Harvey" McGuire. Jan. 27, 1863, while home on furlough, Calvin and Lizzie married. After the War, he returned to the practice of medicine in and around Boon Hill and Millville, before moving his practice to Fayetteville, Jan. 1871. 1872, he was an Alderman in Fayetteville. Was vice president and president of the 1st National Bank of Fayetteville and the 1st vice president of the Lincoln Co., Medical Society. He was a Mason, an Odd Fellow, a Knight of Honor, a Knight of Pythias, a member of the Ancient Order of United Workmen and the Knights and Ladies of Honor (was examining surgeon for the last 4 organizations).

Calvin and Lizzie's home was on a 1987 Walking Tour of Fayetteville, described as an 1850s Italianate, 2 story brick, located at 315 East College St. (and stating the property at 319 College was originally part of the McGuire property).

Extracted from Sketches of Prominent Tennesseans by William S. Speer, pub. 1888; "He began life without patrimony, came out of the war with nothing, but was free from debt, a leading trait in his character being a holy horror of owing any man anything." "Dr. McGuire has a strongly marked character. His intellect is vigorous and healthy." "He has a steady nerve and great skill with the knife, hence has acquired considerable local reputation as a surgeon. Had he a wide field of operation, no doubt his professional character would become very extended, if not national." "He is a gentleman of high moral standing, agreeable manners and fine social qualities. He is a good type of a useful and honorable citizen."