She is the daughter of Abiram Skeel 1774 – 1855 & Lydia Prentice 1778 – 1862.
She married Smith Wix Pickardon Nov 21, 1816 in Camillus, Onondaga, N.Y.
Divorce from Smith Wix Pickard
Their Children: Jonas L. Pickard 1817 – 1875, Palmer Pickard 1820 – 1896, Edwin Pickard 1821 – 1907, Lorenzo Dow Pickard 1822 – 1859, Franklin Pickard 1824 – 1891, Rachel Amelia Pickard 1827 – 1907, Jane Pickard 1829 – 1914, Sarah Marie "Sally" Pickard 1832 – 1922, Albert Pickard 1835 – 1880, Daniel O. Pickard 1837 – 1892, Ira O. Pickard 1839 – 1924, & Harlow Pickard 1842 – 1863.

Obiuary from The Stephenson Farmer, 31 Oct 1879, page 1:

Obituary.
PICKARD. - Died Oct. 20th, 1879, Mrs. Affa Pickard, aged 81 years, 9 months and 20 days.
Affa Skeel was born Jan. 1st, 1798, in Warrenberg, Rensalier county, New York. She was the eldest daughter of a family of twelve children, eight of whom are yet living, four brothers and four sisters. She was converted when seventeen years of age, and united with the M. E. Church, in which she remained during the remainder of her natural life. She was married November 21st, 1816, to S. W. Pickard, and came to Waddams, stephenson county, Ill., in 1838, bring with her a family of seven children, and leaving two in New York. She raised a family of eleven children, ten of whom are yet living, seven sons and three daughters. She had fifty-one grand-children, of which thirty-five are yet living, and seventeen great-grand-children, all living. She died Oct. 20th, 1879, retaining her christian faith and a rational mind until her expiring moments. A few minutes before passing away she said, "Almost gone; all is well' I am going' good-bye!"
Her funeral took place on Sabbath morning last, from the M. E. Church. The church was crowded to is utmost capacity with friends and citizens who had gathered to witness the last sad rites over her who had mingled with them in the many years gone. Rev. Jos. Odgers officiated, delivering an able and feeling discourse from the 14th chapter of Revelations, 1st and 2d verses.