Infirmary Cemetery was used by the old Belmont County Infirmary (Poorhouse) for many years. A great many of the burials are unmarked.

The commissioners of Belmont County on October 18, 1828, under the terms of the act of 1816, purchased for $2,800 a 150 acre farm three miles west of St. Clairsville, Ohio, for the purpose of providing a suitable home for the indigent persons of the county. A brick building standing on the farm was repaired and remodeled for the first "poorhouse." When the institution became crowded in 1843, an addition was built at a cost of $500. Persons suffering from mental ailments who had been admitted to the "poorhouse" were moved to separate quarters constructed in 1847. From time to time improvements and repairs were made on the old building until 1870 when a new four-story brick infirmary was erected on the farm at a cost of $63,000.23.

Besides providing for those who have violated the laws, the commissioners were given the duty of caring for persons who, because of poverty or physical or mental defects, became public charges. Thus, county relief for the indigent, one of the most pressing problems of the twentieth century, was met in frontier Ohio. As early as 1805 an act, modeled from the territorial law, was passed which was similar in all respects to the poor laws of seventeenth century England. Under the early enactments the township trustees were authorized to appoint overseers of the poor. In 1816 the county commissioners were authorized to construct "poor houses" for the care of the indigent of the county. As the system developed in succeeding decades the county was made responsible for those who had become permanently disabled, and for paupers who could not be satisfactorily cared for except at the county infirmary, now call the county home.

The cemetery is at the end of the exit ramp heading west off Interstate 70 on State Route 331.

The cemetery is located in Richland Township, Belmont County, Ohio, and is # 943 (County Home Cemetery) in "Ohio Cemeteries 1803-2003", compiled by the Ohio Genealogical Society.
The U.S. Geological Survey (USGS) Geographic Names Information System (GNIS) feature ID for the cemetery is 1082161 (Infirmary Cemetery / County Home Cemetery).