Son of John and Elizabeth "Betsey" (Scott) Hancock.

Charles was baptized at the old Trinity Church in Boston on April 13, 1811.

Boston Latin Class of 1819. Harvard Class of 1829. While at Harvard, he was a member of the Hasty-Pudding Club. In July of 1829, during Harvard's Class Day, he served as one of the commencement speakers. He was admitted to the bar of Middlesex County in October, 1834. He served as Justice of the Peace. Being the executor of the Hancock Estate, he made donations related to John Hancock, to Harvard College (now Harvard University), Massachusetts Historical Society, New England Historic Genealogical Society (NEHGS), and the Bostonian Society. He died at Boston City Hospital.

"Mr. Charles Lowell Hancock, who died at the City Hospital on the 22d inst., was a grandson [should say grand-nephew] of the distinguished John Hancock. He resided in Chicago, Ill., and was eighty years and one month of age. His father, John Hancock, was a native of Boston, and his mother, Elizabeth, was an Englishwoman by birth. Charles L. Hancock was born in this city and was graduated at Harvard College in 1829. Of the fifty-nine members of the class but nine are now living." - Boston Evening Transcript, April 24, 1890.

"BOSTON, April 24.-Charles Lowell Hancock, grandnephew of John Hancock of Revolutionary fame, was buried this morning in the tomb of the Hancock family in the Granary Burying Ground. The Rev. Dr. Storrs of Brooklyn read the funeral service. Mr. Hancock was a graduate of Harvard, Class of '29. Mr. Hancock was also a graduate of the Harvard Law School, and has resided for the past sixteen years in Chicago, but has been staying for the past seven months with his niece in Brookline. He was eighty years old and a bachelor." – The New York Times, April 25, 1890.

"Mr. Charles Lowell Hancock, grand-nephew of John Hancock of Revolutionary fame, was buried yesterday morning in the tomb of the Hancock family in the Granary Burying Ground. Rev. Dr. Storrs of St. Paul's Church, Brooklyn, read the funeral service. The last time the tomb was opened was in October, 1885, when a brother of Charles was interred there." –Boston Evening Transcript, April 25, 1890.

Cause of death: bronchitis and kidney disease
Undertaker: B.F. Smith

1850 U.S. Census:
https://familysearch.org/ark:/61903/3:1:S3HT-67Q7-6GW?mode=g&i=114&cc=1401638

1860 U.S. Census:
https://familysearch.org/ark:/61903/3:1:33S7-9BSS-5H5?mode=g&i=3&cc=1473181