Louisa was the daughter of Elijah Miles and Rebecca Slatten. She married Marion Kindred Vanderpool, 12 June 1861, and they had 26 children.

Some people have suggested her parents were James Aquilla Miles (1802–1880) and Priscilla Wells (1805–1901).

Have also seen her first name spelled "Sintha".

Kentucky Death Certificate
Name: Louisa Vanderpool
Death Date: 30 Jun 1927
Death Location: Whitley
Age: About 83
Date of Birth: Don't know
Birth Location: Kentucky
Marital Status: Widow
Parents: Don't know on both
Informant: William Waddell
Burial: Nevisdale, KY
Cause of Death: Mitral Regurgitation and Heart Murmur

The Vanderpool Family Probably The Largest in Kentucky: Whitley County Kentucky.
The divine injunction to be "fruitful and multiply, and replenish the earth" has not been more faithfully observed and obeyed since the days of old than by Marion Kennard Vanderpool and his good wife, a typical Kentucky mountain couple, who make their home in the hills of Whitley county. This twain are the parents of twenty-six children, twenty-one of whom they reared to the estate of man and womanhood. The remaining five died in infancy. Mr. and Mrs. Vanderpool, though both far down on the shady side of life, and despite the hardships of poverty and the cares of rearing their large family of sons and daughters are still hale and hearty. Their home is one of comfort and convenience, and is still the roof- tree of several sons and daughters, while to those of the family who have drifted away, the latch string still hangs on the outside. The family ties, welded by parental love and reciprocal affection, are still unbroken, and though the family is scattered to the four winds it is in spirit united still. Each year there is a family reunion, when most of them gather about the old Whitley county home and partake of the parental hospitality and spend a time beneath the roof that sheltered them from the cradle to manhood and womanhood. A few days since, the occasion of what is known among the mountain folk as a "working" in which relatives and neighbors gather to lend a helping hand in rearing a barn, clearing a mountain, or to have a "hog-killing" time, the sons and daughters of the Vanderpool household who dwell still in the mountains of their native county, gather at the old home, bringing with them their own families, to enjoy again the atmosphere of their childhood days and to donate to their aged father a day's toil, that the task of the year in tilling the soil of his mountain farm might be lighter for him in his waning years. The writer, with note book and camera, had the good fortune to be a guest at the Vanderpool home on this occasion, and all facts, figures, views and groups are a valued record, from which this story is compiled. The date of the "working" had been heralded among the sons and daughters several days before, that they might gather in from the mountain valleys where they make the respective homes, and, before the sun peeped above the mountain tops on the gala day, more than a score of stalwart men, armed with axes, saws, briar hooks and other farm implements, set off to a mountain hard by to clear away the obstructions to cultivation. These men, all of rugged constitution, and fine specimens of rugged manhood, all bearing the name of Vanderpool. were sons of the aged couple, one of whom they left at home busy with the personal supervision of the household; the other at the head of the procession to the woods.