Per his obituary:
In 1851 he married Jane Matlock (she died in 1864) with whom he had 3 sons; William, Frank (drowned at Oregon City in 1889) and Herman.

In 1866 he remarried to Sarah E. Fox (still living at the time of his death) with whom he had 4 children: Callie E., Thomas M., George C. and Anna J.

He was of Scotch parents, had a brother named William, and was a personal friend of Dr. Marcus Whitman.
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The following bio was provided by Martin Burrell .

Samuel Learned Campbell arrived in Oregon, with his parents, prior to, 01 Dec 1850, by the overland route. The family came for the free land being given away by the U. S. Congress in the hope of that by this act the Oregon Territory would be securely owned by the United States of America; and this by right of the number of it's citizens living in the Oregon Territory. The Oregon Territory was at that time made up of what would become five states with headquarters in Oregon City, Clackamas, Oregon. It was the first plotted city west of the Mississippi River.

At lease three members of the family applied for and received Oregon Donation Land Claims. They were the father, Hector Campbell, another son Hector B. Campbell and then Samuel L. Campbell. They all three reported to be born in Hampden County, Massachusetts. While Samuel and his father's claimed land were in Clackamas County. His brother, Hector B., found land in what was then a much larger, Washington County. Which was later split up into at least three or four counties. Later, his claim was finalized to be in Multnomah County and not far away from the other claims by family members.

Samuel L. Campbell received ODLC No. 1072, located in Clackamas County; he was born 1824, Hampden County, Mass.; arrived in Oregon Territory, prior to 01 Dec 1850; secured his claim, 15 Nov 1854, by fulfilling all his obligations; one of them being, that he needed to be married because half the land would come through her 'right to claim land'; Samuel was married to Amanda June 'Campbell', on 06 Jan 1852, in Clackamas County, Oregon. The affidavits as to his good character and his fulfilling the contract requirements with the U.S. Federal Government and Land Office, were signed by William B. Campbell, Hector Campbell and W. T. Matlock.