American Patriot
He was in the party that opened Boone's Trace en route to a large tract of land, that became known as Fort Boonesboro, KY, that had been purchased from the Cherokees by his brother, Richard Henderson, a land speculator and representative for North Carolina on the western Virginia/North Carolina survey team and a jurist. That party of men established Fort Boonesboro.

He was a defender of Boonesboro, Ky, under Daniel Boone and Richard Callaway. He was in the party that rescued three girls who had been captured by the Shawnee indians. These girls were: Elizabeth Calloway, whom he afterwards married, her sister, Fanny, (both daughters of Richard Callaway) and Jemima Boone, daughter of Daniel. He was a colonel in the American Revolutionary War.

In old age he lived with his son, Pleasant Henderson, in McMinnville, Warren, TN.

The only known published obituary appeared in the March 21, 1817 issue of the newspaper The Raleigh Minerva : "DIED Lately in Tennessee, Col. Samuel Henderson, aged about 80 years. Col. Henderson was a native of North Carolina, and a man distinguished by a strong and clear understanding."

Samuel's will was probated in Franklin County, TN, in 1816, according to Ron in the research department of the Tennessee State Library Archives.
Name: Samuel Henderson
Birth - Death: 1746-1816
Source Citation:

* Dictionary of North Carolina Biography. Volume 3, H-K. Edited by William S. Powell. Chapel Hill, NC: University of North Carolina Press, 1988. (DcNCBi 3)

Tennessee Records: Tombstone Inscriptions and Manuscripts (1933)

His wife, Elizabeth Callaway Henderson, a daughter of Col. Richard Callaway and Francis Walton, co-founder of Boonesboro, pre-deceased him 15 Aug 1815. Her burial location is unknown.